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Scleral and corneal xanthomatous inflammation in a gray mouse lemur (Microcebus murinus)
Authors:Charline Alleaume  Meryem El Mrini  Eve Laloy  Julia Marchal  Fabienne Aujard  Sabine Chahory
Affiliation:1. Ecole Nationale Vétérinaire d'Alfort, Unité d'Histologie Embryologie et Anatomie pathologique, Université Paris‐Est, Maisons‐Alfort, France;2. Centre National de la Recherche Scientifique, Muséum National d'Histoire Naturelle, Mécanismes Adaptatifs et Evolution, Brunoy, France;3. Ecole Nationale Vétérinaire d'Alfort, UP Ophtalmologie, Université Paris‐Est, Maisons‐Alfort, France
Abstract:Bilateral multifocal corneal opacity was detected in a 4.5‐year‐old male captive gray mouse lemur (Microcebus murinus) without other clinical ocular changes. Histopathological examination revealed a severe diffuse granulomatous scleritis and focal keratitis with intralesional cholesterol, consistent with xanthomatous inflammation. This is the first report of xanthomatous inflammation in a gray mouse lemur. This condition may be the result of systemic factors (lipid metabolism disorders) and/or local predisposing factors such as hemorrhage or inflammation. The pathogenesis in this case could not be fully determined. Further studies on lemurs are required for a better understanding of their lipid metabolism, as well as for diagnosing and evaluating the incidence of xanthomatous inflammation in these species.
Keywords:cornea  gray mouse lemur     Microcebus murinus     sclera  xanthomatous inflammation
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