Myxoma virus induces apoptosis in cultured feline carcinoma cells |
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Authors: | MacNeill A L Moldenhauer T Doty R Mann T |
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Institution: | Department of Pathobiology, College of Veterinary Medicine, University of Illinois, Urbana, IL 61802, USA. almac@illinois.edu |
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Abstract: | There is growing interest in utilizing replicating oncolytic viruses as cancer therapeutics agents. The effectiveness of myxoma virus-induced oncolysis was evaluated in two feline cancer cell cultures. Although myxoma virus is a rabbit-specific pathogen, protein expression driven by myxoma virus and production of infectious viral particles were detected. Cell death occurred in primary feline cancer cells within 48 h of inoculation with myxoma virus. Future studies to determine if other feline neoplasms are susceptible to myxoma virus infection are warranted. |
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