首页 | 本学科首页   官方微博 | 高级检索  
     检索      


Allergic conjunctivitis and conjunctival provocation tests in atopic dogs
Authors:Lourenço-Martins Ana Mafalda  Delgado Esmeralda  Neto Isabel  Peleteiro Maria Conceição  Morais-Almeida Mário  Correia José Henrique Duarte
Institution:CIISA, Faculdade de Medicina Veterinária, Universidade Técnica de Lisboa, Portugal Department of Immunoallergology, Hospital Cuf-Descobertas, Lisboa, Portugal.
Abstract:Introduction Canine atopic dermatitis (cAD) is a very common disease, but little is known about eye involvement. The conjunctival provocation test (CPT) is used in human to study the ocular response to allergenic stimuli and to evaluate anti‐allergic therapy. To our knowledge it has not been used in dogs. Objectives To evaluate the prevalence of ocular signs in a population of atopic dogs and relate these with clinical cAD scores; and the usefulness of CPT for dust mites in atopic dogs with itchy eyes. Procedures Sixty cAD patients were evaluated for (i) ocular signs of allergic conjunctivitis including conjunctival hyperemia, chemosis, epiphora, ocular discharge, pruritus and corneal involvement, graded 0 to 3 according to severity, and (2) cAD Extent and Severity Index (CADESI‐03). Additionally, CPTs for Dermatophagoides farinae (n = 12) and Dermatophagoides pteronyssinus (n = 12) were performed in sensitized atopic dogs and 24 control dogs. Results Periocular and ocular signs of allergy were present in 60% (36/60) of cases. Conjunctival hyperemia (90%) was the most common sign. Severity of ocular signs was significantly correlated with eye pruritus (rs = 0.690, P = <0.001) and skin lesions score for head region (rs = 0.261, P = 0.04). A highly significant difference (P < 0.001, Fisher test) was found in CPTs between the test and the control groups. Conclusion Allergic conjunctivitis signs associated with cAD seem under valuated so these patients would benefit from an ophthalmologic evaluation. Furthermore, we found CPT to be a reliable, easy to perform and safe test for the etiologic diagnosis of allergic conjunctivitis in the dog.
Keywords:allergic conjunctivitis  canine atopic dermatitis  conjunctival provocation test  Dermatophagoides farinae  Dermatophagoides pteronyssinus  house dust mites
本文献已被 PubMed 等数据库收录!
设为首页 | 免责声明 | 关于勤云 | 加入收藏

Copyright©北京勤云科技发展有限公司  京ICP备09084417号