| 烟酸诺氟沙星在松浦镜鲤体内代谢残留规律的研究 |
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| 引用本文： | 段可馨,韩冰,王荻,卢彤岩. 烟酸诺氟沙星在松浦镜鲤体内代谢残留规律的研究[J]. 江西农业大学学报, 2016, 0(2): 356-361. DOI: 10.13836/j.jjau.2016050 |
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| 作者姓名： | 段可馨 韩冰 王荻 卢彤岩 |
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| 作者单位： | 1. 中国水产科学研究院 黑龙江水产研究所，黑龙江 哈尔滨 150070; 东北农业大学 动物科学技术学院，黑龙江哈尔滨 150010;2. 中国水产科学研究院 黑龙江水产研究所，黑龙江 哈尔滨 150070; 上海海洋大学 水产与生命学院，上海 201306;3. 中国水产科学研究院 黑龙江水产研究所,黑龙江 哈尔滨,150070 |
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| 基金项目： | 农业部公益性行业(农业)科研专项经费(201203085)，现代农业产业技术体系建设专项资金( CARS－46) Project supported by the Special Fund for Agro－scientific Research in the Public(201203085)，Interest of China Special Funds of the Modern Agricultural Industry Technology System(CARS－46) |
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| 摘 要： | 分析烟酸诺氟沙星在松浦镜鲤体内代谢残留规律,准确制定该种药物的休药期,为有效、安全、合理地使用烟酸诺氟沙星提供准确科学的理论依据。选用松浦镜鲤(Cyprinus carpio L.)为实验对象,连续5 d口灌30 mg/(kg·d)烟酸诺氟沙星(norfloxacin nicotinate,NFX)后,分别于给药后1,2,3,4,5,6,7,9,11,13,15,20,25 d采集鲤血浆、肌肉、皮、肝和肾5种组织,通过高效液相色谱法检测其各组织内烟酸诺氟沙星的残留量。烟酸诺氟沙星在鲤体内吸收分布迅速,代谢较为缓慢,各组织分布量由多到少依次为:肾脏、肝胰脏、肌肉、皮肤、血浆,为避免组织内残留过多药物,建议休药期为24 d。
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| 关 键 词： | 松浦镜鲤 烟酸诺氟沙星 代谢残留 高效液相色谱法 |
A Study on the Metabolic Residue Rule of Norfloxacin Nicotinate in Common Carp |
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| Abstract: | The aim of this study is to study the residual rule of norfloxacin nicotinate in common carp,for?mulate the withdrawal time of norfloxacin accurately and provide a precision and scientific theory basis for u?sing this medicine reasonably,safely and effectively.In the experiment,common carp(Cyprinus carpio L.)was taken as the target,the fish were drenched with the medicine 30 mg/( kg ·d) for 5 days,then their kidney,liv?er,muscle,skin and blood were collected at the 1st,2nd,3rd,4th,5th,6th,7th,9th,11th,13th,15th,20th,25thday af?ter the medication.The residual of norfloxacin nicotinate in the above 5 kinds of tissues was detected by high performance liquid chromatography(HPLC).Norfloxacin nicotinate was absorbed by the tissues rapidly but me?tabolized slowly.The distribution of the medicine was in the order:kidney>liver>muscle>skin>blood.In order to avoid excessive medicine residues within the tissues,the 24 days of withdrawal time is proposed. |
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| Keywords: | common carp norfloxacin nicotinate metabolic residues high performance liquid chromatogra-phy( HPLC) |
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