Severe calcification of mucocutaneous and gastrointestinal tissues induced by high dose administration of vitamin D in a puppy |
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Authors: | Nakamura Yuka Gotoh Mayumi Fukuo Yoshiko Takei Akihiro Noda Takahiro Murakami Akihiro Kano Rui Watari Toshihiro Tokuriki Mikihiko Hasegawa Atsuhiko Sasaki Yoshihide |
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Affiliation: | Department of Veterinary Internal Medicine, Nihon University School of Veterinary Medicine, Fujisawa, Kanagawa, Japan. |
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Abstract: | A three-month-old male Bull Terrier was referred to the Animal Medical Centre, Nihon University with chief complaints of subacute emesis and lethargy. Severe leukocytosis, high CRP, hypercalcemia and hypochloremia were detected. Moreover, severe calcification of gingival mucosa and abdominal skin, and abnormalities of the skeletal system were discerned. Abdominal X-ray and endoscopic examination revealed ulcer and hemorrhage on the mucosal membrane of the stomach. This might have been due to injections of high dose vitamin D at 3 and 2 weeks ago by another practioner, according to the detailed history of medication. After two months, a gastrointestinal and skin disorder disappeared, although calcification of the stomach membranes remained and abnormality of the skeletal system had worsened. Therefore, vitamin D should be carefully administrated to a puppy. |
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