Evaluation of a Multidrug Chemotherapy Protocol (ACOPA II) in Dogs With Lymphoma |
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| Authors: | Nathaniel C. Myers III Antony S. Moore William M. Rand John Gliatto Susan M. Cotter |
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| Affiliation: | Departments of Medicine, Foster Hospital for Small Animals, Tufts University, School of Veterinary Medicine, North Grafton;Departments of Pathology, Foster Hospital for Small Animals, Tufts University, School of Veterinary Medicine, North Grafton;Department of Community Health, Tufts University School of Medicine, Boston, MA. |
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| Abstract: | A chemotherapeutic protocol using cyclophosphamide, vincristine, prednisone, doxorubicin, and L-asparaginase (ACOPA II) was evaluated in dogs with lymphoma. The response rate for 68 dogs treated with ACOPA II (complete remission [CR] 65%, partial remission [PR] 10%) was lower than that for 41 dogs treated with a related protocol previously evaluated (ACOPA I; CR 76%, PR 12%). Initial treatment with doxorubicin and prednisone did not decrease the prevalence or severity of toxicity during induction. The mortality during induction was 22%. The median duration of CR for dogs treated with ACOPA II was 9 months, with 40% still in remission at 1 year and 21% at 2 years. The rate of CR was lower for dogs with signs of illness at presentation (substage b ) and for dogs weighing less than 15 kg. Age was negatively correlated with survival time and duration of remission. Dogs with immunoblastic lymphoma had a more favorable prognosis than did those with lymphoblastic lymphoma. Survival times were also longer for dogs in substage a at presentation. Seven dogs in which treatment was discontinued while in remission had comparable remission duration to that achieved by dogs receiving long-term maintenance chemotherapy. |
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