| 灵芝提取物对人肝癌SMMC─7721细胞DNA合成的影响 |
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| 引用本文： | 徐朝晖,姜世明.灵芝提取物对人肝癌SMMC─7721细胞DNA合成的影响[J].中国食用菌,1996(1). |
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| 作者姓名： | 徐朝晖 姜世明 |
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| 作者单位： | 山东师范大学生物系 |
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| 摘 要： | 本文以人肝癌ＳＭＭＣ－７７２１细胞为材料，对水溶性灵芝提取物（ＥＧＬ）抗癌作用机理进行了研究。结果表明，ＥＧＬ能明显抑制ＳＭＭＣ－７７２１细胞的ＤＮＡ合成：ＥＧＬ在５０ｕｇ／ｍｌ到３００ｕｇ／ｍｌ范围表现出明显的剂量效应；ＥＧＬ最小有效作用剂量为１００ｕｇ／ｍｌ，最大有效作用剂量为３００ｕｇ／ｍｌ。结果提示ＥＧＬ的抗癌机理主要是通过抑制癌细胞ＤＮＡ合成而起作用的。
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| 关 键 词： | 芝灵，人肝癌细胞，DNA合成 |
THE EFFECT OF EGL ON THE DNA SYNTHESIS OF HUMAN HEPATOMA CELL LINE SMMC-7721 |
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| Xu Zhaohui, Jiang Shiming.THE EFFECT OF EGL ON THE DNA SYNTHESIS OF HUMAN HEPATOMA CELL LINE SMMC-7721[J].Edible Fungi of China,1996(1). |
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| Authors: | Xu Zhaohui Jiang Shiming |
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| Abstract: | In this paper,the effect of EGL (Extraction of Ganoderma lucidum)on the DNA synthesis of human hepatoma cell line SMMC-7721 was studied,The results demonstrated that(1)the EGL could significantly inhibite the DNA synthesis of SMMC-7721 cells.(2)The inhibitory activity showed a possitive dose relativity from 50ug EGL/ml to 300ug EGL/ml/(3)The minimum active dose of EGL was l00ug/ml,the maximum was 300 ug/ml.From the results, we could conclude that the anticancer activity of the EGL was mainly by inhibiting DNA synthesis of the cancer cells. |
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| Keywords: | Ganoderma lucidum Human Hepatoma SMMC-7721 DNA Synthesis |
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