Anti-Liver Membrane Protein Antibodies in Dogs With Chronic Hepatitis |
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| Authors: | Douglas J. Weiss P. Jane Armstrong Asha Mruthyunjaya |
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| Affiliation: | Department of Veterinary PathoBiology and the Department of Small Animal Clinical Sciences, College of Veterinary Medicine, University of Minnesota, St. Paul, MN |
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| Abstract: | Serum from 21 dogs with chronic hepatitis was evaluated for anti-liver membrane protein (anti-LMP) antibodies by an enzyme-linked immunosorbent assay. Ten of the 21 dogs had anti-LMP antibody concentrations greater than 2 SD above the mean value for the 10 healthy control dogs; titers ranged from 1:40 to greater than 1:1,600. Anti-LMP—positive dogs were not restricted by breed, had higher alanine amino transferase activity and total bilirubin concentration, and more severe liver lesions when compared with anti-LMP—negative dogs. This study provided evidence of humoral autoantibodies in dogs with chronic hepatitis, but it did not determine if the autoantibodies were primary or secondary. |
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