Interferon-gamma in the serum and effusions of cats with feline coronavirus infection |
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Authors: | Giordano Alessia Paltrinieri Saverio |
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Institution: | aDepartment of Veterinary Pathology, Hygiene and Public Health, University of Milan, Via Celoria 10, 20133 Milan, Italy |
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Abstract: | The aim of this study was to quantify and compare interferon-γ (IFN-γ) concentrations in the serum of clinically normal cats infected with feline coronavirus (FCoV) with its concentration in the sera and effusions of cats with feline infectious peritonitis (FIP), a disease associated with infection with a mutated form of FCoV.Clinically normal FCoV-infected cats living in catteries with a high prevalence of FIP had the highest serum IFN-γ concentrations. The serum concentration of IFN-γ was not significantly different in cats with FIP compared with clinically normal FCoV-infected animals living in catteries with a low prevalence of the disease. Moreover, the concentration of IFN-γ was significantly higher in the effusions than in the serum of cats with FIP, probably due to IFN-γ production within lesions. These findings support the hypothesis that there is a strong, ‘systemic’ cell mediated immune response in clinically normal, FCoV-infected cats and that a similar process, albeit at a tissue level, is involved in the pathogenesis of FIP. |
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Keywords: | Feline coronavirus (FCoV) Feline infectious peritonitis (FIP) Interferon-γ (IFN-γ ) ELISA Cell mediated immunity |
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