The clinical biochemistry of experimentally produced lupinosis in the sheep |
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Authors: | JG ALLEN AG RANDALL† |
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Institution: | *Animal Health Laboratories, Department of Agriculture, South Perth, Western Australia 6151;†Department of Clinical Biochemistry, Queen Elizabeth II Medical Centre, Verdun Street, Nedlands, Western Australia 6009 |
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Abstract: | Lupinosis was produced in sheep in four experiments by administering a toxic extract of Phomopsis leptostromiformis by various routes and at various dose rates. The course of the intoxication was followed by plasma biochemical analyses for a number of electrolytes, metabolites and enzymes. Results from these analyses suggested that in addition to being an hepatotoxicity, lupinosis also resulted in injury to muscle, kidney and adrenal cortex. This was confirmed by microscopic examination of these tissues. |
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