KIT-positive gastrointestinal stromal tumours in two Spanish ibex (Capra pyrenaica hispanica) |
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Authors: | Velarde Roser Mentaberre Gregorio Sánchez Joaquín Marco Ignasi Lavín Santiago |
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Institution: | Servei d'Ecopatologia de Fauna Salvatge, Facultat de Veterinària, Universitat Autònoma de Barcelona, 08193 Bellaterra, Barcelona, Spain. Roser.Velarde@uab.es |
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Abstract: | Gastrointestinal mesenchymal tumours from two Spanish ibex (Capra pyrenaica hispanica) were examined grossly, histologically and immunohistochemically. One neoplasm was a 1.5 kg tan multinodular cavitated mass in the forestomach. The other tumour was a firm mural mass 1.2 cm in diameter in the colon. Microscopically, both tumours were formed mainly by spindle shaped cells arranged in closely packed interlacing fascicles. Neoplastic cells in both tumours labelled positively for KIT (CD117), vimentin and alpha-smooth muscle actin. These findings suggest that both neoplasms were gastrointestinal stromal tumours and most likely to be derived from the interstitial cells of Cajal or their progenitor cells. |
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Keywords: | Gastrointestinal stromal tumours Spanish ibex Capra pyrenaica hispanica Interstitial cells of cajal Immunohistochemistry KIT |
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