Neutrophil function in sheep experimentally infected with bovine leukemia virus |
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| Authors: | A F Walker J H Lumsden T Stirtzinger |
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| Institution: | 1. Department of Experimental Medicine I, Nikolaus-Fiebiger Center of Molecular Medicine, University of Erlangen-Nürnberg, 91054 Erlangen, Germany;2. Department of Biochemistry II, Faculty of Medicine, Oita University, Oita 879-5593, Japan;3. Metabolic Health Research, TNO, NL-2333CK Leiden, The Netherlands;4. Department of Molecular and Clinical Pharmacology, Institute of Translational Medicine, The University of Liverpool, Liverpool, England;5. Institute of Experimental and Clinical Pharmacology and Toxicology, University of Erlangen-Nürnberg, 91054 Erlangen, Germany;6. Institute of Biochemistry, Microbiology and Genetics, University of Regensburg, 93053 Regensburg, Germany;7. Department of Ophthalmology, University of Erlangen-Nürnberg, 91054 Erlangen, Germany;8. Department of Dermatology and Cutaneous Biology, Thomas Jefferson University, Philadelphia, PA 19107, USA;1. Department of Economics, Stockholm University, S-106 91 Stockholm, Sweden;2. Economics Department, University of Southampton, UK;3. Economics Department, UniCredit & Universities Fellow, Central European University, Budapest, Hungary;4. IZA, Bonn, Germany;5. CESIfo, Munich, Germany |
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| Abstract: | In vitro neutrophil adherence, random migration, chemotaxis, resting and phagocytosis-associated oxygen consumption and bactericidal responses were assessed in sheep experimentally infected with bovine leukemia virus (BLV). Neutrophil function was examined in two groups of 9 control and 9 BLV-infected sheep at 0, 1, 2, 3, 5, 7, 11 and 15 weeks post-infection. Enhanced neutrophil adherence, chemotaxis and resting oxygen consumption responses were found in the infected group at 2, 11 and 15 weeks respectively. Significant alterations between groups were not demonstrated during the other time intervals. |
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