Gene expressions of canine angiopoietin-1 and -2 in normal tissues and spontaneous tumours |
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| Authors: | Kato Y Asano K Mizutani I Konno T Sasaki Y Kutara K Teshima K Edamura K Kano R Suzuki K Shibuya H Sato T Hasegawa A Tanaka S |
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| Institution: | Laboratory of Veterinary Surgery, Department of Veterinary Medicine, College of Bioresource Sciences, Nihon University, Kameino 1866, Fujisawa, Kanagawa 252-8510, Japan. |
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| Abstract: | The angiopoietin (Ang) family of proteins are central to the regulation of angiogenesis. The purposes of this study were to determine cDNA sequences of canine Ang-1 and Ang-2 and investigate their expressions in normal tissues and spontaneous tumours. The cDNA sequences of canine Ang-1 and Ang-2 were 1,494 and 1,488 bp, and the deduced amino acid sequences were 497 and 495 residues, respectively. The cDNA sequences of canine Ang-1 and Ang-2 showed high homology with those of the other mammalian species. Canine Ang-1 and Ang-2 mRNA were detectable in all 22 normal tissues and spontaneous tumours. Higher mRNA expression level of canine Ang-2 was demonstrated in mammary simple carcinomas, haemangiosarcoma and hepatocellular carcinoma in comparison with normal tissues. |
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| Keywords: | Angiogenesis Angiopoietin Dog Tumour Vascular endothelial growth factor |
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