抗生素工业化生产中一级种子罐染菌原因及解决方法

抗生素工业化生产中,菌种往往需要扩大繁殖到一定的数量后再进入发酵罐.在一级种子制备过程中,引起染菌的因素很多,极大地影响了抗生素生产的产量和质量.解决一级种子罐染菌的方法,除制定科学的岗位SOP并不断提高操作者的技能外,更重要的是要加强工艺管理,树立以预防为主的思想,根据微生物特性,强化环境清洁,加强设备清洁、维修,操作时实行定人、定操作.

Reasons and solutions for the bacteria contamination on the first-class germ container in the process of producing antibiotic

There are many factors which cause the bacteria contamination in the preparation process of the first-class germ. And the percentage of the bacteria contamination in the first-class germ container is higher than that in fermentation container. It affects the output and the quality of production of antibiotic greatly. In order to avoiding the bacteria contamination in first-class germ container,it must be done to improve the skills of operators and operated with SOP . The most important are to strengthen the management in process, to improve the sanitation and hygiene of environment, to reinforce the clearance, inspection and reparation for equipments, to implement fixed workers and operations in the process.