Endothelial interleukin-8: a novel inhibitor of leukocyte-endothelial interactions |
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| Authors: | M A Gimbrone M S Obin A F Brock E A Luis P E Hass C A Hébert Y K Yip D W Leung D G Lowe W J Kohr |
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| Institution: | Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115. |
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| Abstract: | Certain inflammatory stimuli render cultured human vascular endothelial cells hyperadhesive for neutrophils. This state is transient and reversible, in part because activated endothelial cells secrete a leukocyte adhesion inhibitor (LAI). LAI was identified as endothelial interleukin-8 (IL-8), the predominant species of which is an extended amino-terminal IL-8 variant. At nanomolar concentrations, purified endothelial IL-8 and recombinant human IL-8 inhibit neutrophil adhesion to cytokine-activated endothelial monolayers and protect these monolayers from neutrophil-mediated damage. These findings suggest that endothelial-derived IL-8 may function to attenuate inflammatory events at the interface between vessel wall and blood. |
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