Lack of arrhythmogenicity of aminophylline in dogs |
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Authors: | R. L. HAMLIN J. L. SALLY |
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Affiliation: | Department of Veterinary Physiology and Pharmacology, College of Veterinary Medicine, The Ohio State University, Columbus, Ohio, USA;Department of Veterinary Physiology and Pharmacology, College of Veterinary Medicine, The Ohio State University, 1900 Coffey Road, Columbus, OH 43210-1092, USA |
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Abstract: | This study was designed to determine if doses of aminophylline up to 10 mg/kg given i.v. would produce ventricular arrhythmias in seven healthy dogs anaesthetized with fentanyl-dropelidol-pentobarbital. Arrhythmias were sought by inspection of ECGs before and after attempts at provoking them with 5 pg/ kg boluses of epinephrine given i.v., or by programmed electrical stimulation. After cumulative doses of 10 nig aminophylline/kg body weight, producing an estimated plasma concentration of greater than 30 pginil, no ventricular ectopia other than escape depolarizations were observed. We were unable t o document an arrhythmogenic effect of aminophylline when given rapidly by the i.v. route. I t is possible that the anaesthetic regimen reduced the arrhythmogenic property of aminophylline, or that arrhythmias might be produced in either obese or ill dogs; but it is unlikely that chronic administration of aminophylline would be more arrhythmogenic. |
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