Histological differences in full-thickness vs. lamellar corneal pig-to-rabbit xenotransplantation |
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| Authors: | Joo Youn Oh†‡ Mee Kum Kim†‡ Jung Hwa Ko†‡ Hyun Ju Lee†‡ Chung-gyu Park‡§ Sang Joon Kim‡¶ Won Ryang Wee†‡ Jin Hak Lee† |
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| Institution: | Seoul Artificial Eye Center, Seoul National University Hospital Clinical Research Institute, Seoul, Korea;;Department of Ophthalmology, Seoul National University College of Medicine, Seoul, Korea;;Xenotransplantation Research Center and Clinical Research Institute, Seoul National University Hospital, Seoul, Korea;;Department of Microbiology and Immunology, Seoul National University College of Medicine, Seoul, Korea;;Department of Surgery, Seoul National University College of Medicine, Seoul, Korea |
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| Abstract: | To evaluate the differences in graft survival and histopathological characteristics between full-thickness and lamellar orthotopic corneal xenotransplantation in a pig-to-rabbit model, we orthotopically transplanted a full-thickness or the anterior half of a pig's cornea onto the OD of 16 rabbits. As a result, the median survival were 16.83 and 29.07 days for the full-thickness and lamellar xenografts, respectively ( P = 0.0005). Histologically, the full-thickness corneal xenografts had massive infiltration by eosinophils, whereas the lamellar xenografts showed predominantly mononuclear infiltrates ( P < 0.05). Given these preliminary findings, lamellar corneal xenografts in rabbits survived longer than the full-thickness xenografts and each type of graft demonstrated different rejection mechanisms. |
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| Keywords: | cornea full-thickness lamellar penetrating xenotransplantation |
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