Acetophenone glycosides from thyme (Thymus vulgaris L.). |
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| Authors: | M Wang H Kikuzaki C C Lin A Kahyaoglu M T Huang N Nakatani C T Ho |
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| Institution: | Department of Food Science, Rutgers, The State University of New Jersey, New Brunswick, NJ 08901-8520, USA. |
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| Abstract: | Four acetophenone glycosides were isolated from the butanol-soluble fraction of thyme extracts. Their structures were determined by spectral methods (MS, NMR, and 2D-NMR). Among them, two new compounds, 4-hydroxyacetophenone 4-O-5-O-(3, 5-dimethoxy-4-hydroxybenzoyl)-beta-D-apiofuranosyl]-(1-->2)-beta-D -gl ucopyranoside (1) and 4-hydroxyacetophenone 4-O-5-O-(4-hydroxybenzoyl)-beta-D-apiofuranosyl]-(1-->2)-beta-D-+ ++gluc opyranoside (2), were determined. Compound 1 showed weak cytotoxicity, inhibiting DNA synthesis of human leukemia cells. |
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