Inhibition of pro-inflammatory enzymes by inuviscolide, a sesquiterpene lactone from Inula viscosa |
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| Authors: | Máñez Salvador Hernández Victoriano Giner Rosa-María Ríos José-Luis Recio María Del Carmen |
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| Institution: | Departament de Farmacologia, Facultat de Farmàcia, Universitat de València, Avinguda Vicent Andrés Estellés s/n, 46100 Burjassot, Spain. manez@uv.es |
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| Abstract: | This work concerns the pharmacological activity of inuviscolide, a sesquiterpenoid from Inula viscosa. It exerts inhibitory effects on elastase, cyclooxygenase 1 and secretory phospholipase A(2). Furthermore, it reduces the skin leukocyte infiltration in a murine model of dermatitis induced by repeated application of 12-O-tetradecanoylphorbol 13-acetate. |
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| Keywords: | Inula viscosa Pro-inflammatory enzymes Dermatitis |
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