Sulfoxaflor and the sulfoximine insecticides: Chemistry,mode of action and basis for efficacy on resistant insects |
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| Authors: | Thomas C. Sparks Gerald B. WatsonMichael R. Loso Chaoxian GengJon M. Babcock James D. Thomas |
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| Affiliation: | Dow AgroSciences, 9330 Zionsville Road, Indianapolis, IN 46268, United States |
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| Abstract: | The sulfoximines, as exemplified by sulfoxaflor ([N-[methyloxido[1-[6-(trifluoromethyl)-3-pyridinyl]ethyl]-λ4-sulfanylidene] cyanamide] represent a new class of insecticides. Sulfoxaflor exhibits a high degree of efficacy against a wide range of sap-feeding insects, including those resistant to neonicotinoids and other insecticides. Sulfoxaflor is an agonist at insect nicotinic acetylcholine receptors (nAChRs) and functions in a manner distinct from other insecticides acting at nAChRs. The sulfoximines also exhibit structure activity relationships (SAR) that are different from other nAChR agonists such as the neonicotinoids. This review summarizes the sulfoximine SAR, mode of action and the biochemistry underlying the observed efficacy on resistant insect pests, with a particular focus on sulfoxaflor. |
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| Keywords: | GPA, green peach aphid (Myzus persicae) IRM, insecticide resistance management IRAC, Insecticide Resistance Action Committee MTH, 2-CH3-thiazole nAChR, nicotinic acetylcholine receptors SAR, structure activity relationships SFI, sulfoximine insecticide SFX, sulfoxaflor TFT, tertrahydrofuran |
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