Chemical constituents of Kigelia pinnata twigs and their GLUT4 translocation modulatory effect in skeletal muscle cells |
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Authors: | Khan Mohammad Faheem Dixit Preety Jaiswal Natasha Tamrakar Akhilesh Kumar Srivastava Arvind Kumar Maurya Rakesh |
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Institution: | a Medicinal and Process Chemistry Division, CSIR-Central Drug Research Institute, Lucknow 226 001, Indiab Biochemistry Division, CSIR-Central Drug Research Institute, Lucknow 226 001, India |
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Abstract: | Phytochemical investigation of the ethanolic extract of twigs of Kigelia pinnata DC. afforded one new iridoid 7-hydroxy eucommiol (1), and nine known compounds (2-10). The structure of compounds was elucidated by extensive spectroscopic methods, including 1D, 2D NMR experiments and MS analysis. All these compounds were evaluated for GLUT4 translocation modulatory effect in skeletal muscle cells. Four of the tested compounds 1, 5, 6 and 7 showed significant stimulation of GLUT4 translocation to cell surface in skeletal muscle cells without any adverse effect on cell viability. Effect of these four compounds was concentration-dependent and comparable to standard drug rosiglitazone. These findings indicate that constituents of K. pinnata may provide leads for the therapeutics for insulin resistance and diabetes. |
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Keywords: | Diabetes mellitus Kigelia pinnata Iridoids GLUT4 translocation |
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