Bioactive phenolics from the fruits of Livistona chinensis |
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Authors: | Zeng Xiaobin Wang Yihai Qiu Qian Jiang Chenguang Jing Yuntiao Qiu Guofu He Xiangjiu |
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Affiliation: | a School of Pharmaceutical Sciences, Wuhan University, and Key Laboratory of combinatorial Biosynthesis and Drug Discovery (Wuhan University), Ministry of Education, Wuhan 430071, Chinab Department of Pharmacy Office, Renmin Hospital of Wuhan University, Wuhan 430060, Chinac Guangdong Dexin Pharmaceutical Company, Jiangmen 529100, China |
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Abstract: | This study investigated the antioxidant and cytotoxic activity of the phenolics isolated from the fruits of Livistona chinensis. Four new compounds, 1-{ω-isoferul[6- (4-hydroxybutyl)pentadecanoic acid]}-glycerol (1), E-[6′-(5″-hydroxypentyl)tricosyl]-4-hydroxy-3-methoxycinnamate (2), 2-(3′-hydroxy-5′-methoxyphenyl)-3-hydroxylmethyl-7-methoxy-2,3-dihydrobenzofuran-5- carboxylic acid (3), 7-hydroxy-5,4′-dimethoxy-2-arylbenzofuran (4), together with eleven known phenolics (5-15), were isolated and identified. Among these compounds, 1-4, 5-O-caffeoylshikimic acid (5), caffeic acid (7), and 3-O-caffeoylshikimic acid (8) showed potent antioxidant activity. 1-5, and 8 showed potent antiproliferative activities with IC50 values among 5-150 μM against HepG2 human liver cancer, HL-60 human myeloid leukemia, K562 human myeloid leukemia, and CNE-1 human nasopharyngeal carcinoma cell lines. On the basis of these findings, it could be proposed that the fruits of L. chinensis may serve as attractive mines of powerful anticancer and antioxidant agents for various purposes. |
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Keywords: | Livistona chinensis 1-(ω-isoferuloylalkanoyl)-glycerol Long-chain trans-ferulate Benzofuran Antioxidant activity Antiproliferative activity |
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