A new 9-nor-atractylodin from Atractylodes lancea and the antibacterial activity of the atractylodin derivatives |
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| Authors: | Chen Yanjun Wu Yuxue Wang Hexiang Gao Kun |
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| Affiliation: | a School of Biotechnology and Chemical Engineering, Ningbo Institute of Technology, Zhejiang University; Ningbo, 315100, PR Chinab State Key Laboratory of Applied Organic Chemistry, College of Chemistry and Chemical Engineering, Lanzhou University, Lanzhou, 73000, PR China |
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| Abstract: | A new compound, namely, 9-nor-atractylodin (1) and one known atractylodin (2) were isolated from the rhizomes of Atractylodes lancea. The structural modifications of atractylodin were carried out and a series of atractylodin derivatives (3-10) were obtained. The antibacterial activities of 1-10 were examined against Escherichia coli, Staphylococcus aureus, Bacillus subtilis and Candida albicans. Compounds 4 and 8, which contained the α, β-unsaturated carbonyl fragment, were found to be active against E. coli and S. aureus. |
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| Keywords: | Atractylodes lancea 9-Nor-atractylodin Antibacterial activity |
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