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| 5-氟尿嘧啶在小鼠结肠癌模型中的药效与毒性评价研究 | |
| 引用本文： | 唐雪莲,付京花,PARK Hyun,杨新颖.5-氟尿嘧啶在小鼠结肠癌模型中的药效与毒性评价研究[J].华南农业大学学报,2012,33(4):535-538. |
| 作者姓名： | 唐雪莲 付京花 PARK Hyun 杨新颖 |
| 作者单位： | 1. 华南农业大学动物科学学院,广东广州,510642 2. 韩国圆光大学医学院,全罗北道益山 570749,韩国 3. 中国科学院上海药物研究所,上海,201203 |
| 基金项目： | Science and Technology，国家自然科学基金 |
| 摘 要： | 为探讨5-氟尿嘧啶的药效、毒性与给药剂量之间的关系,采用BALB/c小鼠来源的CT26结肠癌细胞株构建小鼠结肠癌模型,分别给予10、20、30和50 mg/kg剂量的5-氟尿嘧啶,分析其抗肿瘤效果、对小鼠体质量的影响和死亡率等指标.结果表明,5-氟尿嘧啶的体内抑瘤效果及毒性与剂量密切相关.综合分析评价各指标,认为20～30 mg/kg剂量的5-氟尿嘧啶较适合于小鼠结肠癌模型中的药效评价. |
| 关 键 词： | 5-氟尿嘧啶 药效 毒性 结肠癌 |
| 收稿时间： | 4/1/2012 12:00:00 AM |
Efficacy and Toxicity of 5-Fluorouracil in Colon Cancer Treatment of a Mouse Syngeneic Model |
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| TANG Xue-lian , FU Jing-hua , PARK Hyun , YANG Xin-ying.Efficacy and Toxicity of 5-Fluorouracil in Colon Cancer Treatment of a Mouse Syngeneic Model[J].Journal of South China Agricultural University,2012,33(4):535-538. | |
| Authors: | TANG Xue-lian FU Jing-hua PARK Hyun YANG Xin-ying |
| Institution: | 1 College of Animal Science, South China Agricultural University,;1 College of Animal Science, South China Agricultural University,;2 School of Medicine, Wonkwang University,;3 Shanghai Institute of Materia Medica, Chinese Academy of Sciences, |
| Abstract: | To investigate the relationship of anticancer effects, toxicity and dose, tumor syngeneic models were made from murine colorectal adenocarcinoma cell line CT26 derived from BALB/c mice. Mice were treated with various doses (10, 20, 30 and 50 mg/kg) of 5-fluorouracil (5-FU), and the indexes were analyzed, including the anti-tumorigenic effects, body mass and mortality of mice. The results showed that the efficacy and toxicity of 5-FU was closely related to the doses, and the proposal dose was 20-30 mg/kg which may be the optimal dose for drug research in tumor syngeneic model of mice. |
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