肠球菌毒力因子研究进展

肠球菌(Enterococcus)是人和动物肠道的正常菌群,通常不引起发病,为一种重要的机会致病菌.最近几年,由于免疫制剂的广泛使用,侵入性治疗机会的增加和抗生素的过渡使用,尤其是第3代头孢菌素的广泛应用,使得肠球菌的感染不断上升,成为医院内感染的主要致病菌.肠球菌致病机制与其致病岛编码的毒力因子表面蛋白、溶血素、蛋白明胶酶等有关,肠球菌致病机理不是由单一毒力因子所决定,而是多种毒力因子共同作用的结果.文章综述了肠球菌的各种潜在毒力因子的生物特性及其与致病性的关系,为预防和控制肠球菌感染提供参考.

Advance in Enterococcal Virulence Factors

Enterococcus are commensals of the intestinal tract of humans and animals and major opportunistic pathogens.In recent years,because of abuse of antibiotics and immunity preparation,and increasing of invasive treatment,especially the third cephalosporins,leading to enterococcal infections incessantly raising,enterococci have become major nosocomial opportunistic pathogens.The pathogenic mechanism of enterococci is relative to the virulence factors Esp,cyl,gelE,et al,which coded by Pathogenicity Island(PAI).The pathogenic mechanism of enterococci is not determined by single but multi-virulence factors.This review described the biological characteristics and the pathogenicity of enterococcal virulence factors.These can provide directions to prevent and control the enterococcal infections.