Systemic inflammatory response syndrome,sepsis, and antimicrobial therapy |
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| Affiliation: | 1. Department of Animal and Food Sciences, University of Delaware, Newark, Delaware;2. Department of Clinical Studies, New Bolton Center, University of Pennsylvania, Kennett Square, Pennsylvania;1. Faculty of Medicine, King Abdulaziz University, Jeddah, Saudi Arabia;2. Elemental Spectroscopy Unit, King Fahd Medical Research Center, King Abdulaziz University, Jeddah, Saudi Arabia;3. Medical Education and Metabolic Medicine, Brighton and Sussex Medical School, University of Brighton, BN1 9PH, UK |
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| Abstract: | Neonatal sepsis is a serious and often fatal disease of the foal. Research has documented that the clinical syndrome which results from bacterial infection of the neonate is the result of a widespread and florid inflammatory response which is termed the systemic inflammatory response syndrome (SIRS). Successful treatment of affected individuals is possible, and an important component of the treatment is the proper use of antimicrobials. Proper selection of antimicrobials requires the consideration of several important factors including the infecting organism, toxicity, and route of administration, cost, and metabolism of the antimicrobial. In most cases, antimicrobial treatment can be discontinued when localizing signs of infection are absent, and the temperature and complete blood cell count have been normal for 72 hours. |
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