Effect of the liquid form of traditional Chinese medicine,Hozen-S,on
gastric motility in dogs |
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| Authors: | Yuta SHINOHARA Mohamed ELBADAWY Megumi YAMANAKA Haru YAMAMOTO Amira ABUGOMAA Tatsuya USUI Kazuaki SASAKI |
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| Institution: | 1)Laboratory of Veterinary Pharmacology, Department of Veterinary Medicine, Faculty of Agriculture, Tokyo University of Agriculture and Technology, Tokyo, Japan;2)Pet Health & Food Division, Iskara Industry Co., Ltd., Tokyo, Japan;3)Department of Pharmacology, Faculty of Veterinary Medicine, Benha University, Elqaliobiya, Egypt;4)Faculty of Veterinary Medicine, Mansoura University, Dakahliya, Egypt |
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| Abstract: | Juzen-taiho-to, a traditional Chinese herbal medicine, is used for patients with anorexia and fatigue in human medicine. In our previous study, granulated Juzen-taiho-to improved vincristine-induced gastrointestinal adverse effects through increasing gastric motility in dogs. As the effect of Hozen-S, the sweet liquid form of Juzen-taiho-to, on dog gastric motility has not been investigated, we examined the effect of administration of Hozen-S on gastric motility. Furthermore, we assessed dog plasma ghrelin level to further elucidate the mechanism of the effect of Hozen-S on gastric contraction. Finally, we assessed the palatability of Hozen-S compared to granulated Juzen-taiho-to and its effect on body weight in dogs. Administration of Hozen-S significantly increased gastric motility, plasma ghrelin concentration, and body weight. A palatability evaluation revealed that the dogs preferred Hozen-S to granulated Juzen-taiho-to. In conclusion, Hozen-S administration to dogs promoted gastric motility by raising plasma ghrelin levels. Considering these functional and palatability data, Hozen-S may replace granulated type Juzen-taiho-to and become a prominent traditional Chinese veterinary medicament. |
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| Keywords: | dog gastric motility ghrelin Hosen-S traditional Chinese medicine |
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