不同种属动物对强力霉素的反应

给马、骡、驴静注强力霉素过程中出现强烈反应,甚至由于虚脱而立即引起死亡。为此,我们研究了强力霉素对不同种属动物的影响。强力霉素溶于5%葡萄糖液中制成0.1％浓度给驴快速(18—20毫升/分钟)静注过程中,当注入量达到一定量时(40—80毫克),立即产生虚脱反应而倒地。同时证明,这一反应不是赋形剂丙二醇所引起。中速(5毫升/分钟)或慢速(2毫升/分钟注射,则无明显症状出现,但这两种方法在兽医上是不适应的给马驴肌注强力霉素,1、5—5毫克/公斤体重,5分钟后也可出现严重不良反应,主要表现为不安、腹痛、打滚、呼吸加快、心跳加快、肌颤等。一般经60—30分钟后症状渐失。给牛、羊、猪、鸡、狗、猫,兔和豚鼠不论静注、肌注或腹腔注射强力霉素均安全。我们认为,马,骡、驴对强力霉素存在有特异性反应。在兽医上静注或肌注强力霉素均不能用于马、骡、驴。

Effcts of Doxycycllne on Different Kinds of Anlmals

IV administration of doxvcvcline in horse, mule and dookey induced intense reactions, ever immediate death as a result of collapse. For this reason, we have studied the effects of doxycvcline on different kinds of animals. Doycycline was dissolued iu 5％ glucose solution and 0.1% concentration preparedwhen IV administratron at high speed (18-20 ml/min.) was pdrformed in donkey. And the dosage arrived at a artain level (40-180 mg) in blood, it resulted in immediate collapse and falling down on the ground. And it proved that this adverse re-actions had nothing to do with vehicle of proplene glycol. When 0.1％ preoaration IV is performed at moderate-speed (5ml/min.) or slow speed (2ml-min.), there are no obvious svmptoms. but these administrations are not applied by veterinarians. When IM administration of doxycycline was performed in horse and donkey, 1.5-5mg/kg body weight, serious adverse reaction appeared after 5 mins of injection, including unstable, abdominal pain, rolling on the grouno, short of breath, tachycardia, trembling etc.. These symptoms disappeared about 60-130mins after iniection. IV, IM or IP administration of dcxycycline in cattle, sheep, pig, chicken, dog, cat, rabbit and guinea pig are all quite safe. It mavg be thought by the investigaters that doxycycline has special reaction on horse, mule and donkey. IV or IM administration of doxycycline in horse mule and donkey is not applied in veterinary.