Effects of α2-adrenergic drugs on small intestinal motility in the horse: An in vitro study |
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| Authors: | Chiara Zullian Alessandro Menozzi Cristina Pozzoli Enzo Poli Simone Bertini |
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| Institution: | a Department of Animal Health, University of Parma, Parma 43126, Italy;b Department of Human Anatomy, Pharmacology and Medico-Forensic Sciences, University of Parma, Parma 43100, Italy |
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| Abstract: | The effects of selective α2-agonists (xylazine, detomidine and medetomidine) and antagonists (yohimbine and atipamezole) on in vitro small intestine motility in the horse were evaluated. Samples of equine jejunum were placed in isolated organ baths and drug-induced modifications of motility were measured by means of an isotonic transducer. All tested α2-agonists dose-dependently reduced both spontaneous and electrically-evoked phasic contractions. Conversely, α2-antagonists were ineffective when tested alone, and showed a heterogeneous and dose-independent ability to inhibit agonist activity. In particular, the antagonism exerted by higher concentrations of both yohimbine and atipamezole against α2-agonists was weaker than when lower concentrations were used. The data are indicative of the presence of both pre- and post-synaptic α2-adrenoceptors with inhibitory activity on equine jejunum motility, and support a possible therapeutic utility of these drugs in horse intestinal disorders associated with hypermotility. |
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| Keywords: | α 2-Agonists α 2-Antagonists Horse Small intestine Motility |
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