Functional CpG methylation system in a social insect |
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| Authors: | Wang Ying Jorda Mireia Jones Peter L Maleszka Ryszard Ling Xu Robertson Hugh M Mizzen Craig A Peinado Miguel A Robinson Gene E |
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| Affiliation: | Department of Cell and Developmental Biology, University of Illinois at Urbana-Champaign, Urbana, IL 61801, USA. |
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| Abstract: | DNA methylation systems are well characterized in vertebrates, but methylation in Drosophila melanogaster and other invertebrates remains controversial. Using the recently sequenced honey bee genome, we present a bioinformatic, molecular, and biochemical characterization of a functional DNA methylation system in an insect. We report on catalytically active orthologs of the vertebrate DNA methyltransferases Dnmt1 and Dnmt3a and b, two isoforms that contain a methyl-DNA binding domain, genomic 5-methyl-deoxycytosine, and CpG-methylated genes. The honey bee provides an opportunity to study the roles of methylation in social contexts. |
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