吸入糖皮质激素联合穴贴对哮喘患儿免疫功能的影响

目的：探讨吸入糖皮质激素和联合中药穴贴对小儿哮喘免疫功能的影响。方法：30例哮喘患儿随机分为布地奈德干粉（普米克都保）吸入15例（简称普米克组）和中药穴贴（天灸）联合普米克都保吸入组15例（简称联合治疗组），健康对照组15例。分别在治疗前、治疗后1、3个月测定PEFR值．并于治疗前、治疗后3个月测定血清IL-12、IL-4、IL-8水平（采用ELISA法）。以日记的形式记录哮喘日间、夜间症状及使用p2受体激动剂万托林的次数，判断临床疗效。结果：治疗1个月后．两组PEFR值均有明显改善（P〈0．05或〈0．01），治疗3个月后全部患者的PEFR值均上升至正常预测值的90％以上。联合治疗组的日问及夜间症状消失时间较普米克组快（P〈0．01）．且联合治疗组使用万托林的剂量比普米克组明显减少（P〈0．01）。两组患者治疗前IL-4及IL-8水平均明显高于正常对照组．IL-12水平则明显低于正常对照组（P〈0．01）；治疗3个月后复查血清IL-4、IL-8水平明显下降，IL-12明显上升，均恢复至正常对照组水平。结论：两组药物治疗方法均能影响哮喘患儿的血清细胞因子水平；联合治疗组临床症状改善较普米克组迅速。

Effect of corticosteroid inhalation and acupoint sticking on immune function in asthmatic children

Objective: To study the effect of corticosteroid inhalation and acupoint sticking on immune function in asthmatic children. WTHZMethods: Thirty children with asthma were randomly divided into two even groups: pulmicort group received pulmicort inhaler, and combination group accepted pulmicort inhaler and acupoint sticking. The peak expiratory flow rate (PEFR) and serum IL-4, IL-8 and IL-12 levels were determined before and 1, 3 months after treatment. Results: There was an obvious improvement of PEFR in 2 groups after treatment (P<0.05 or 0.01), especially in 3 months. The symptom disappearance was quicker, and ventolin dose was less in combination group compared with pulmicort grounp (P<0.01). Serum IL-4, IL-8 and IL-12 levels returned to normal 3 months after treatment in 2 groups. Conclusion: Both of treatment schedules can affect serum cytokine contents in asthmatic children. Combined therapy can achieve rapid alleviation of clinical symptoms.