抗球虫药新剂型的制备与研究

采用固体分散技术,利用溶剂法,以处方比例马度米星铵:聚维酮(聚乙烯吡咯烷酮,PVPk30)分别为1:1、1:2、1:3制备了3个马度米星铵固体分散体,通过差示扫描量热法(DSC)分析鉴定,当马度米星铵与PVP k30的比例为1:3时马度米星铵的药物特征吸热峰消失,说明固体分散体制备成功。对药物进行体外累积溶出度研究,结果马度米星铵固体分散体在60 min内体外累积溶出度可达98.46%,比马度米星铵预混剂的2.57%提高了38倍多。抗球虫效果研究表明,马度米星铵固体分散体的抗球虫指数(ACI)为197.7,明显高于ACI为191.8的马度米星铵预混剂。

Preparation and research of a new dosage form of anticoccidial drug

Solid dispersion technique was explored to prepare maduramicin ammonium solid dispersions by solvent method,which maduramicin ammonium and providone(PVP k30)was in proportion of 1:1,1:2,1:3 respectively.Differential scanning calorimetry(DSC) was used to examine the physical and chemical characteristics of solid dispersions.The results showed that the characteristic peak of maduramicin ammonium disappeared when the proportion of maduramicin ammonium and PVP k30 was 1:3,suggesting that maduramicin ammonium solid dispersion had been prepared.Dissolution rate of maduramicin ammonium solid dispersion was 98.46%,more than 38 times comparing with that of maduramicin ammonium premix.Anti-coccidia index(ACI) of the maduramicin ammonium solid dispersion was 197.7.