4-Leucine-oxytocin: natriuretic, diuretic, and antivasopressin polypeptide |
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Authors: | W Y Chan V J Hruby G Flouret V Du Vigneuad |
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Abstract: | During water diuresis in anesthetized rats, 4-leucine-oxytocin increased the urine output and the rates of sodium and chloride excretion. The potassium excretion rate was only slightly increased. During vasopressin-suppressed water diuresis, 4-leucine-oxytocin produced similar effects on urine and electrolyte excretions. In addition, it inhibited the vasopressin-induced free-water reabsorption, and it could reverse reabsorption to freewater clearance. |
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