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| 抗菌肽CecropinB对人工感染大肠杆菌雏鸡的治疗效果研究 | |
| 引用本文： | 王秀青,朱明星,张婵,张爱君,杨风琴,哈丽娜,陈溥言. 抗菌肽CecropinB对人工感染大肠杆菌雏鸡的治疗效果研究[J]. 中国家禽, 2011, 33(11) |
| 作者姓名： | 王秀青 朱明星 张婵 张爱君 杨风琴 哈丽娜 陈溥言 |
| 作者单位： | 1. 宁夏医科大学检验学院,宁夏银川,750004 2. 宁夏医科大学实验动物中心,宁夏银川,750004 3. 宁夏人民医院综合科,宁夏银川,750012 4. 南京农业大学农业部动物疫病诊断与免疫重点开放实验室,江苏南京,210095 |
| 基金项目： | 宁夏医科大学特殊人才引进项目 |
| 摘 要： | 以1日龄来航蛋雏鸡为试验对象,研究重组抗菌肽CecropinB治疗雏鸡大肠杆菌感染的效果.120只雏鸡分6个组,每组20只,其中不同剂量抗菌肽治疗组又分为口服和肌内注射两个不同的处理,每个处理10只.致死剂量大肠杆菌肌内注射24 h后,肌内注射和口服不同浓度的重组CecropinB抗菌肽,连续治疗5 d.结果表明,重组抗菌肽CecropinB对大肠杆菌病有较好的治疗效果.其中高剂量(0.75 mL)口服组的效果最佳,治愈率达到80%,中剂量(0.5 mL)口服组与高剂量肌内注射组治愈率同为70%.中剂量肌内注射组与环丙沙星组效果一致,治愈率达到60%,低剂量抗菌肽治疗组治疗效果不如上述所有治疗组.与感染对照组相比,所有组别的雏鸡死亡率显著降低. |
| 关 键 词： | 雏鸡 大肠杆菌 致死剂量 肌内注射 口服 |
Treatmeat Study of Recombinant Antibacterial Peptide CecropinB for Artificial Infected Chickens with Escherichia coli |
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| WANG Xiuqing,ZHU Mingxing,ZHANG Chan,ZHANG Aijun,YANG Fengqin,HA Lina,CHEN Puyan. Treatmeat Study of Recombinant Antibacterial Peptide CecropinB for Artificial Infected Chickens with Escherichia coli[J]. China Poultry, 2011, 33(11) | |
| Authors: | WANG Xiuqing ZHU Mingxing ZHANG Chan ZHANG Aijun YANG Fengqin HA Lina CHEN Puyan |
| Affiliation: | WANG Xiuqing1,ZHU Mingxing2,ZHANG Chan3,ZHANG Aijun1,YANG Fengqin1,HA Lina1,CHEN Puyan4(1.School of Clinical Laboratory of Medicine,Ningxia Medical University,Yinchuan,Ningxia 750004,2.Experiment Animal Centre,3.Comprehensive Division of Ningxia People's Hospital,Ningxia 750012,4.Key Laboratory of Animal Disease Diagnosis and Immunology,Ministry of Agriculture,Nanjing Agricultural University,Nanjing,Jiangsu 210095) |
| Abstract: | In order to test the effect of hybrid antimicrobial peptide cecropinB on E.coli infected chicken,120 one-day-age chickens were separated into six groups at random.In the treating experiment,the chickens treated with different concentration recombinant antibacterial peptide cecropinB by injection,oral administration after 24 h of E.coli infection with the dosage of MLD100.This treatment was lasted five days.The results showed that the recombinant antibacterial peptide cecropinB had preferable bioactivity in ... |
| Keywords: | chickens Escherichia coli MLD100 intramuscular injection oral administration |
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