| 豆类丝核菌次级代谢产物抗肿瘤作用的病理学观察 |
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| 引用本文： | 杨鸣琦,张黎,周宏超,路宏朝,黄增荣. 豆类丝核菌次级代谢产物抗肿瘤作用的病理学观察[J]. 西北农业学报, 2003, 12(4): 5-7 |
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| 作者姓名： | 杨鸣琦 张黎 周宏超 路宏朝 黄增荣 |
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| 作者单位： | 西北农林科技大学动物科技学院,陕西杨凌,712100 |
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| 基金项目： | 国家自然科学基金资助项目(30270979). |
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| 摘 要： | 通过建立种植性肝癌(H22)实体瘤动物模型,并给荷瘤小鼠灌胃含有苦马豆素(swainsonine,SW)且剂量分别为2.7mg·kg-1·d-1和16.2mg·kg-1·d-1的豆类丝核菌次级代谢产物稀释液,分别于灌药后8d、16d剖检荷瘤动物并取肿瘤组织与肝组织制做石蜡切片,HE染色,普通光镜观察。结果表明,该次级代谢产物能抑制种植性实体瘤(H22)的生长和转移。因此,该次级代谢产物具有抗肿瘤药用价值。
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| 关 键 词： | 豆类丝核菌 苦马豆素 次级代谢产物 肿瘤 H22 |
| 文章编号： | 1004-1389(2003)04-0005-03 |
| 收稿时间： | 2003-08-25 |
| 修稿时间： | 2003-08-25 |
The Pathology Observation of Antitumor Effects of Secondary Metabolites of Rhizoctonia Leguminicola |
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| YANG Ming-qi,ZHANG Li,ZHOU Hong-chao,LU Hong-zhao and HUANG Zeng-rong. The Pathology Observation of Antitumor Effects of Secondary Metabolites of Rhizoctonia Leguminicola[J]. Acta Agriculturae Boreali-occidentalis Sinica, 2003, 12(4): 5-7 |
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| Authors: | YANG Ming-qi ZHANG Li ZHOU Hong-chao LU Hong-zhao HUANG Zeng-rong |
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| Affiliation: | College of Animal Science and Technology, Northwest Sci-Tech University of Agriculture and Forestry, Yangling Shaanxi 712100, China;College of Animal Science and Technology, Northwest Sci-Tech University of Agriculture and Forestry, Yangling Shaanxi 712100, China;College of Animal Science and Technology, Northwest Sci-Tech University of Agriculture and Forestry, Yangling Shaanxi 712100, China;College of Animal Science and Technology, Northwest Sci-Tech University of Agriculture and Forestry, Yangling Shaanxi 712100, China;College of Animal Science and Technology, Northwest Sci-Tech University of Agriculture and Forestry, Yangling Shaanxi 712100, China |
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| Abstract: | During the study,we built cancer mold by transplanting Hepatoma 22 cells to rats,and pour the secondary metabolites of Rhizoctonia leguminicola which had swainsonine into the stomach of the rats,and the doses of swainsonine were 2.7 mg·kg-1·d-1 and 16.2 mg·kg-1·d-1 separatdy.the pathology changer were observed.The result showed that the secondary metabolites can inhibit tumor growth and metastasis.Above all,the secondary metabolites of Rhazoctonaa legumanacola have similar function with swainsonine.And they have value as antitumor drugs. |
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| Keywords: | Rhizoctonia leguminicola Swainsonine Secondary metabolites Tumour H_(22) |
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