A new diterpene from the leaves of Andrographis paniculata Nees |
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| Authors: | Chong Xu Gui Xin Chou Zheng Tao Wang |
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| Institution: | 1. The MOE Key Laboratory for Standardization of Chinese Medicines, Institute of Chinese Materia Medica, Shanghai University of Traditional Chinese Medicine, Shanghai 201210, PR China;2. Shanghai R&D Center for Standardization of Chinese Medicines (SCSCM), Shanghai 201210, PR China |
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| Abstract: | Phytochemical investigation of the ethanol extract of the leaves of Andrographis paniculata yielded one novel diterpene (13R, 14R) 3, 13, 14, 19-tetrahydroxy-ent-labda-8 (17), 11-dien-16, 15-olide 1 which has an uncommon cis-diol groups in the lactone moiety, and 3, 19-isopropylidene-14-deoxy-ent-labda-8 (17), 13-dien-16, 15-olide 2, probably an artifact diterpene, together with eight known diterpenoids 3–10. The structures of these compounds were determined on the basis of spectral methods. The structure and stereochemistry of 1 was confirmed by X-ray crystallographic analyses. |
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| Keywords: | Andrographis paniculata ent-labdane diterpenoids X-ray crystallographic analyses |
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