Triterpenoids from Calophyllum inophyllum and their growth inhibitory effects on human leukemia HL-60 cells |
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| Authors: | Yan-Zhi Li Zhan-Lin Li Shi-Liang Yin Guang Shi Ming-Sheng Liu Yong-Kui Jing Hui-Ming Hua |
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| Institution: | 1. Key Laboratory of Structure-Based Drug Design & Discovery, Ministry of Education, Shenyang Pharmaceutical University, Shenyang 110016, PR China;2. School of Traditional Chinese Medica Materia, Box 49, Shenyang Pharmaceutical University, Shenyang 110016, PR China;3. School of Pharmacy, Jining Medical College, Rizhao 276826, PR China;4. School of Life Science and Biopharmaceutics, Shenyang Pharmaceutical University, Shenyang 110016, PR China;5. Department of Pharmacy, Hainan Medical College, Haikou 571101, PR China;6. Mount Sinai School of Medicine, New York, NY 10029, USA |
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| Abstract: | A new friedelane-type triterpene (1), along with seven known triterpenoids, was isolated from the stems and leaves of Calophyllum inophyllum Linn. Their structures were established as 3β, 23-epoxy-friedelan-28-oic acid (1), friedelin (2), epifriedelanol (3), canophyllal (4), canophyllol (5), canophyllic acid (6), 3-oxo-friedelan-28-oic acid (7), and oleanolic acid (8) by spectroscopic methods (NMR, EI-MS). The growth inhibitory effects of these triterpenoids on human leukemia HL-60 cells were determined. |
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| Keywords: | Calophyllum inophyllum Linn Friedelane-type triterpene 3β 23-epoxy-friedelan-28-oic acid Cell growth inhibition Leukemia HL-60 |
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