Two new bufadienolides from the rhizomes of Helleborus thibetanus Franch |
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| Authors: | Jian Yang Yan-hong Zhang Fang Miao Le Zhou Wei Sun |
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| Affiliation: | 1. College of Science, Northwest A&F University, Yangling 712100, PR China;2. College of Life, Northwest A&F University, Yangling 712100, PR China;3. Department of Chemistry, Northwest University, Xi''an 710068, PR China |
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| Abstract: | Two new bufadienolides, named tigencaoside A(1) and tigencaoside B(2), were isolated from the rhizomes of Helleborus thibetanus Franch., along with two known bufadienolides, hellebrigenin (3) and 5β,14β-dihydroxy-19-oxo-3β-[(α-L-rhamnopyranosyl)oxy]bufa-20,22-dienolide (4). Their structures were elucidated on the basis of extensive spectroscopic analysis. Two new compounds were evaluated for their cytotoxic activities against four strains of cultured tumor cells. |
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| Keywords: | Helleborus thibetanus Franch Bufadienolides Tigencaosides A and B |
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