Two 22S-solanidine-type steroidal alkaloids from Fritillaria anhuiensis |
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| Authors: | Qing Yao Shou Qing Tan Zheng Wu Shen |
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| Institution: | 1. School of Pharmacy, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, People''s Republic of China;2. Basilea Pharmaceutical China Ltd., Haimen, Jiangsu 226100, People''s Republic of China |
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| Abstract: | Phytochemical investigation of the fresh bulbs of Fritillaria anhuiensis S. C. Chen et S. E. Yin, resulted in the isolation of a known steroidal alkaloid solanidine of (22S,25S)-solanid-5-en-3β-ol (1), which has never yet been found as a natural substance, and of a new steroidal alkaloid (22S,25S)-solanid-5,20(21)-dien-3β-ol. Compounds 1 and 2 were the first solanidine-type alkaloids with 22-S configuration discovered from nature. Their structures were elucidated based on spectroscopic analysis, including 1D and 2D NMR experiments. |
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| Keywords: | Fritillaria anhuiensis Solanidine Steroidal alkaloid |
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