Anti-inflammatory and analgesic properties of cis-mulberroside A from Ramulus mori |
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Authors: | Zuofa Zhang Liangen Shi |
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Institution: | 1. College of Animal Science, Zhejiang University, Hangzhou 310029, China;2. Institute of Horticulture, Zhejiang Academy of Agricultural Science, Hangzhou 310021, China |
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Abstract: | This study examined the analgesic and anti-inflammatory actions of cis-mulberroside A isolated from Ramulus mori in several models of inflammatory pain in mice. Cis-mulberroside A (25 and 50 mg/kg) given by p.o. route 30 min before challenge produced a dose-dependent inhibition of the acetic acid-induced pain and Evans blue leakage in mice. In addition, this compound exhibited significant systemic anti-inflammatory activity in carrageenan-induced mouse paw edema in a concentration-related manner (33.1–68.5% inhibition), and similar results were achieved in formalin test. Suppressive effects of cis-mulberroside A on the production of NO and expression of inducible nitric oxide synthase (iNOS) in lipopolysaccharide (LPS)-stimulated macrophages were also assessed. Collectively, cis-mulberroside A showed high analgesic and anti-inflammatory activities. The above results will be the supporting evidence for the potential anti-rheumatoid activity of R.mori in Chinese traditional medicine. |
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Keywords: | Cis-mulberroside A Ramulus mori Analgesic activity Anti-inflammatory |
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