Reproductive and developmental toxicity evaluation of a purified Arabinogalactan-Protein (AGP) composition in Wistar rats |
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Authors: | Salim Tamboli Sudershan AroraUpendra Bhatnagar Gururaj VishwaseMinakshi Singh |
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Institution: | Novel Drug Discovery and Development (NDDD), Lupin Ltd., 46A/47A, Nande Village, Mulshi Taluka, Pune 411042, India |
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Abstract: | A purified Arabinogalactan-Protein composition (LL-4218) was prepared from the leaves of Argemone mexicana to treat psoriasis. The effect of (LL-4218) was evaluated on reproductive (male and female fertility) and developmental toxicity in rats. LL-4218 was administered orally at the doses of 250, 500 and 1000 mg kg− 1. The results showed that LL-4218 did not produce any significant dose related changes in reproductive and developmental toxicity studies. Therefore, it is concluded that LL-4218 did not produce any significant toxic effect on reproduction and developmental parameters of rats and NOAEL for reproductive and developmental toxicity studies in rats was 1000 mg kg− 1. |
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Keywords: | Argemone mexicana Psoriasis Arabinogalactan-Protein LL-4218 Developmental toxicity Reproductive toxicity |
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