Puerarin exhibits weak estrogenic activity in female rats |
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| Authors: | Suchinda Malaivijitnond Duangjai Tungmunnithum Sarocha Gittarasanee Kanya Kawin Nathachit Limjunyawong |
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| Affiliation: | 1. Primate Research Unit, Department of Biology, Faculty of Science, Chulalongkorn University, Bangkok, 10330, Thailand;2. Department of Biology, Faculty of Science and Technology, Nakorn Sawan Rajabhat University, Nakornsawan Province, Thailand |
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| Abstract: | A weak estrogenicity of puerarin on reproductive organs was addressed in female rats. In short-term treatment, immature ovariectomized rats were injected with 0.7 mg/kg BW/day of puerarin, for 14 days. Puerarin did not increase uterus weights, endometrium and myometrium areas, and the percent of cornified cells (%Co), but it increased the number of uterine glands. In long-term treatment, mature rats were injected with 7.0 mg/kg BW/day of puerarin for 140 days. Puerarin did not increase uterus weights, endometrium and myometrium areas, and the number of uterine glands, but a significant increase in the %Co was observed from day 98 onwards. |
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| Keywords: | Estradiol valerate Pueraria mirifica Puerarin Uterus Uterine gland Vagina |
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