A secoiridoid with quinone reductase inducing activity from Cortex fraxini |
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| Authors: | Lijun Wang Fang Sun Xiaoyu Zhang Zhongjun Ma Lin Cheng |
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| Affiliation: | 1. Institute of Pharmaceutical Informatics, School of Pharmaceutical Sciences, Zhejiang University, Zijingang Campus, No. 388 Yuhangtang Road, Hangzhou 310058, PR China;2. Zhejiang Academy of Traditional Chinese Medicine, No. 132 Tianmushan Road, Hangzhou 310058, PR China |
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| Abstract: | A new secoiridoid named chinensisol (1) along with twenty known compounds were isolated from the 95% ethanol extract of Cortex fraxini. Their structures were elucidated on the basis of NMR, MS, IR and UV spectral evidences. The quinone reductase (QR) inducing activities of the compounds were evaluated and the results showed that compounds 1, 9 and 14 had moderate QR inducing activities with CD values (concentration required to double the specific activity of QR) of 72.4 ± 7.7, 34.3 ± 3.3 and 42.0 ± 0.4 μM respectively. |
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| Keywords: | Cortex fraxni Secoiridoid Quinone reductase |
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