Antidiarrhoeal activity of carbazole alkaloids from Murraya koenigii Spreng (Rutaceae) seeds |
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| Authors: | Suvra Mandal Anupam Nayak Manoj Kar Samir K Banerjee Ashes Das SN Upadhyay RK Singh Avijit Banerji Julie Banerji |
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| Institution: | 1. Centre of Advanced Studies on Natural Products including Organic Synthesis, Department of Chemistry, Calcutta University, 92, A.P.C. Road, Kolkata – 700009, India;2. Department of Chemistry, National Research Institute of Ayurveda for Drug Development, Bidhannagar, Kolkata – 700091, India;3. Department of Pharmacology, National Research Institute of Ayurveda for Drug Development, Bidhannagar, Kolkata – 700091, India;4. Biochemistry Unit, Neonatology, Institute of Post Graduate Medical Education and Research, Kolkata – 700020, India |
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| Abstract: | The bioassay guided fractionation of the n-hexane extract of the seeds of Murraya koenigii Spreng (Rutaceae) resulted in the isolation of three bioactive carbazole alkaloids, kurryam (I), koenimbine (II) and koenine (III). The structures of the compounds were confirmed from their 1H-, 13C-, and 2D-NMR spectral data. Of the three compounds (I) and (II) exhibited significant inhibitory activity against castor oil-induced diarrhoea and PGE2-induced enteropooling in rats. The compounds also produced a significant reduction in gastrointestinal motility in the charcoal meal test in Wister rats. |
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| Keywords: | Murraya koenigii Carbazole alkaloid Seed Antidiarrhoeal |
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