3-Prenyl luteolin,a new prenylated flavone with melanin biosynthesis inhibitory activity from wood of Artocarpus heterophyllus |
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Authors: | Enos Tangke Arung Kuniyoshi Shimizu Hiroyuki Tanaka Ryuichiro Kondo |
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Institution: | 1. Department of Forest Products Technology, Faculty of Forestry, Mulawarman University, Samarinda, Indonesia;2. Department of Systematic Forest and Forest Products Sciences, Faculty of Agriculture, Kyushu University, Japan;3. Department of Medicinal Resources Regulation, Faculty of Pharmaceutical Sciences, Kyushu University, Japan |
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Abstract: | In our efforts to find new whitening agent from natural resources, we focused on wood of Artocarpus heterophyllus which shows anti-melanogenesis activity. By activity-guided fractionation of A. heterophyllus wood extract, a new prenylated flavonoid, 3-prenyl luteolin (1) was isolated. The IC50 of mushroom tyrosinase inhibitotry activity of 1 was 76.3 µM. The results of the comparison with that of luteolin showed the prenyl substituent at C-3 position of 1 play an important role for revealing tyrosinase inhibition. In melanin formation inhibition on B16 melanoma cells, IC50 of 1 was 56.7 µM with less cytotoxicity. |
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Keywords: | Artocarpus heterophyllus Tyrosinase Melanin 3-Prenyl-3&prime 4&prime 5 7-tetrahydroxyflavone 3-Prenyl luteolin B16 melanoma cells |
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