Ayurvedic processed seeds of nux-vomica: Neuropharmacological and chemical evaluation |
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| Authors: | Chandrakant Katiyar Abhishek Kumar SK Bhattacharya RS Singh |
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| Institution: | 1. 323/S, 1st Floor, Southend Floors, Sector 48-49, Sohna Road, Gurgaon (HR), India;2. Department of Pharmaceutical Sciences, Birla Institute of Technology, MESRA, Ranchi, India;3. Department of Pharmacology, Institute of Medical Sciences, Banaras Hindu University, Varanasi, India;4. Department of Rasashashtra and Bhaisajya kalpana, Institute of Medical Sciences, Banaras Hindu University, Varanasi, India |
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| Abstract: | The effect of detoxification on Strychnos nux-vomica seeds by traditional processing with aloe and ginger juices (B), by frying in cow ghee (C), and by boiling in cow milk (D) was investigated. The ethanolic extracts of these samples were subjected to spontaneous motor activity (SMA), pentobarbitone-induced hypnosis, PTZ induced convulsions, diazepam-assisted protection, and morphine-induced catalepsy. All samples reduced SMA and inhibited catalepsy. The seeds processed in milk (D) showed the lowest strychnine content in the cotyledons, exhibited marked inhibition of PTZ induced convulsions and maximal potentiation of hypnosis, and were the safest (LD50). |
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| Keywords: | Ayurvedic processings CNS stimulant Detoxification Neuropharmacology Strychnos nux-vomica Shodhan |
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