The response of the supramammary lymph node of the sheep to secondary infection with orf virus |
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| Authors: | D J McKeever H W Reid |
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| Affiliation: | 1. Montefiore Medical Center and Albert Einstein College of Medicine, Department of Obstetrics & Gynecology and Women''s Health, Bronx, NY, United States of America;2. Albert Einstein Cancer Center, Albert Einstein College of Medicine, Bronx, NY, United States of America;1. Department of Pediatrics A, Schneider Children Medical Center, Israel;2. Division of Hematology Oncology, Schneider Children Medical Center, Israel;3. Felsenstein Medical Research Center, Sackler Faculty of Medicine, Tel Aviv University, Israel;1. Health Psychology, University of Leuven, Belgium;2. REVAL - Rehabilitation Research Center, Faculty of Medicine and Life Sciences, Hasselt University, Diepenbeek, Belgium;3. Centre for Translational Psychological Research (TRACE), Hospital ZOL, Limburg, Genk, Belgium;4. Department of Psychiatry, University Hospital Gasthuisberg, Leuven, Belgium;5. Laboratory for Brain-Gut Axis Studies (LaBGAS), Translational Research Center for Gastrointestinal Disorders (TARGID), University of Leuven, Belgium;1. Laboratory of functional and environmental ecology, Faculty of Sciences and Techniques, Sidi Mohammed Ben Abdellah University, BP 2202 Imouzzer Road, Fez, Morocco;2. Laboratory of Research and Development virology, MCI Animal Health, Lot. 157, Zone Industrielle Sud-Ouest (ERAC) B.P: 278, Mohammedia 28810, Morocco;3. Departement of Experimental Animal Facilities and Biorisk Management, Collection of Cell Lines in Veterinary Medicine, Friedrich-Loeffler-Institut, Federal Research Institute for Animal Health, Südufer 10, D-17493 Greifswald - Insel Riems, Germany |
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| Abstract: | The response of the supramammary lymph node of seven sheep to secondary infection with orf virus was examined by cannulating the efferent lymphatic before infecting the drainage area of the node. All animals developed typical orf lesions and responded after an initial lag period with an increase in total cell output paralleled by a rising proportion of lymphoblast cells. Most lymphoblast contained immunoglobulin with a predominance of the IgG class. When cultured, these cells produced measurable amounts of virus-specific antibody. The proportion of cells which stained with a T-cell-specific monoclonal antibody was measured in two of the sheep and found to decrease as the response developed. These data suggest that the nodal response is directed mainly towards the production of virus-specific antibody. The extent of T-cell involvement remains unclear. |
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