| 双孢蘑菇子实体多糖的提取及其对癌细胞的抑制 |
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| 引用本文： | 徐朝晖,姜世明.双孢蘑菇子实体多糖的提取及其对癌细胞的抑制[J].中国食用菌,1997,16(4):5-7. |
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| 作者姓名： | 徐朝晖 姜世明 |
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| 作者单位： | 山东师范大学和物系，山东省动物抗性重点实验室 |
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| 摘 要： | 双孢蘑菇子实体（Ａｇａｒｉｃｕｓｂｉｓｐｏｒｕｓ）经热水提取，乙醇沉淀，胰蛋白酶消化，Ｓｅｖａｇ法去除蛋白质等处理，得多糖。经紫外可见光分光光度计测定无紫外吸收峰，为较纯多糖。并研究了其对人肝癌ＳＭＭＣ－７７２１细胞生长曲线、有丝分裂指数及线粒体活性的影响，结果表明该多糖对体外培养的人肝癌ＳＭＭＣ－７７２１细胞增殖有一定抑制作用，抑癌实验证明该多糖对小鼠Ｓ－１８０实体瘤亦有一定抑制作用。
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| 关 键 词： | 双孢蘑菇子实体 多糖 抑瘤 |
Isolation of Polysacchrides From the Bodies of Agaricus bisporus Sing. and Its Inhibitory on Human Hepatoma SMMC-7721 Cells |
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| Xu Zhaohui,Jiang Shiming,FU Peiwu.Isolation of Polysacchrides From the Bodies of Agaricus bisporus Sing. and Its Inhibitory on Human Hepatoma SMMC-7721 Cells[J].Edible Fungi of China,1997,16(4):5-7. |
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| Authors: | Xu Zhaohui Jiang Shiming FU Peiwu |
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| Abstract: | The polysacchride was isolated from the fruit bodies of Agaricus bisporus Sing. and verified by ultraviolet spectrum. The proliferation of human hepatoma SMMC-7721 cell line was significantly inhibited by the treatment of 50ug/mL the polysacchride. The conclusion was proved by determining the variation of the growth curve, mitosis index and mitochodria activity. The inhibitory activity of the polysacchride against implanted S-180 tumor in mice was also perfromed with the 51.9% inhibition. |
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| Keywords: | Agaricus bisporus Sing polysacchride |
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