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Genome of the host-cell transforming parasite Theileria annulata compared with T. parva |
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| Authors: | Pain Arnab Renauld Hubert Berriman Matthew Murphy Lee Yeats Corin A Weir William Kerhornou Arnaud Aslett Martin Bishop Richard Bouchier Christiane Cochet Madeleine Coulson Richard M R Cronin Ann de Villiers Etienne P Fraser Audrey Fosker Nigel Gardner Malcolm Goble Arlette Griffiths-Jones Sam Harris David E Katzer Frank Larke Natasha Lord Angela Maser Pascal McKellar Sue Mooney Paul Morton Fraser Nene Vishvanath O'Neil Susan Price Claire Quail Michael A Rabbinowitsch Ester Rawlings Neil D Rutter Simon Saunders David Seeger Kathy Shah Trushar Squares Robert Squares Steven Tivey Adrian |
| Institution: | Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SA, UK. ap2@sanger.ac.uk |
| Abstract: | Theileria annulata and T. parva are closely related protozoan parasites that cause lymphoproliferative diseases of cattle. We sequenced the genome of T. annulata and compared it with that of T. parva to understand the mechanisms underlying transformation and tropism. Despite high conservation of gene sequences and synteny, the analysis reveals unequally expanded gene families and species-specific genes. We also identify divergent families of putative secreted polypeptides that may reduce immune recognition, candidate regulators of host-cell transformation, and a Theileria-specific protein domain frequently associated in Theileria (FAINT)] present in a large number of secreted proteins. |
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