Two new amide alkaloids with anti-leukaemia activities from Aconitum taipeicum |
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Authors: | Ying Xu Zeng Jun Guo Nan Wu |
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Institution: | a Faculty of Pharmacy, Medical College of Xi'an Jiaotong University, Xi'an 710061, People's Republic of China |
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Abstract: | Two new amide alkaloids, named 3-isopropyl-tetrahydropyrrolo 1,2-a] pyrimidine-2,4(1H,3H)-dione (1) and 1-acetyl-2,3,6-triisopropyl-tetrahydropyrimidin-4(1H)-one (2), were isolated from the roots of Aconitum taipeicum. Their chemical structures were characterized on the basis of MS, 1D- and 2D NMR. The anti-leukaemia activities of the compounds were also tested. The results indicated that the compounds exhibited more significant cell growth inhibitory activities against HL-60 cells than adriamycin, with the IC50 of 1.1 ± 0.03 μg/mL and 1.6 ± 0.07 μg/mL respectively. In addition, two compounds showed anti-tumor activities against K562 cells as well. |
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Keywords: | Aconitum taipeicum Amide alkaloids Anti-leukaemia activity |
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